Abstract
The survival rate of lung cancer can be significantly improved by monitoring biomarkers in exhaled air that indicate diseases in early stage, so it is very important to develop micro analytical systems which can offer a fast, on-site, real-time detecting biomarkers in exhaled air. In this paper, a mini-gas chromatography (GC)-photo-ionization detector (PID) system integrated with a micro GC column and a micro pre-concentrator was developed for forming an inexpensive, fast, and non-invasive diagnostic tool for lung cancer. This system has very strong concentrate ability owing to its integrated micro pre-concentrator, which make the detection of trace components in exhaled air very easy. In addition, the integrated micro GC column can separate complex mixtures, which overcome low resolution and poor anti-interference ability of other instruments. The results indicated that the mini-GC-PID system can effectively separate and detect the biomarkers at parts-per-billion (ppb) level.
Highlights
Lung cancer is the leading cause of death in the world today; its diagnosis very often happens late in the course of the disease since available diagnostic methods are not sufficiently sensitive and specific
Fast, and non-invasive diagnostic tool for lung cancer, in this paper, a mini-gas chromatography (GC)-photoionization detector (PID) system integrated with a micro GC column and a micro pre-concentrator was developed, and this system had very strong concentrate ability, which makes detection of trace components in exhaled air very easy
The results indicated that the mini-GC-photo-ionization detector (PID) system can effectively separate and detect biomarkers at ppb level
Summary
Lung cancer is the leading cause of death in the world today; its diagnosis very often happens late in the course of the disease since available diagnostic methods are not sufficiently sensitive and specific. There are strong evidences [1,2,3,4] to suggest that lung cancer can be detected by molecular analysis of exhaled air in the early stage. Breath analysis represents a new diagnostic technique that is without risk for the patient; it is very important to develop microanalytical systems which can offer a fast, label-free, low cost, no damage and on-site monitoring biomarkers of lung cancer in exhaled air. Gordon et al [4] developed a nanoelectronic nose which can diagnose cancers and kidney failure by monitoring breath biomarkers, opening up a new approach for diagnosing diseases in the early stage
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