Detection and significance of blood lipid and oxidative stress in subclinical hypothyroidism during preg-nancy

Abstract

Objective To explore the change and significance of blood lipid and oxidative stress in subclinical hypothyroidism during pregnancy. Methods 100 pregnant women with subclinical hypothyroidism during pregnancy were chosen and set as the disease group, while 100 healthy pregnant women were chosen and set as the control group. Thyroid function index: free three iodine thyroid original glycine (FT3) , free thyroid hormones (FT4) , thyroid stimulating hormone (TSH) , blood lipids index: triglyceride (TG) , total cholesterol (TC) , high density lipoprotein cholesterol (HDL-C) , low density lipoprotein cholesterol (LDL-C) , and oxidative stress indicators: superoxide dismutase (SOD) , malondialdehyde (MDA) , type oxidized low density lipoprotein (ox-LDL) in the two groups were detected and analyzed. Results FT3 and FT4 between the two groups had no statistical significance (P>0.05) . TSH in the disease group was (4.63±1.09) mIU/L, significantly higher than that of the control group (P 0.05) . TC and LDL-C in the disease group were significantly higher than those of the control group (P<0.05) . MDA and ox-LDL in the disease group were significantly higher than those of the control group, while SOD was significantly lower than that of the control group (P<0.05) . Conclusion Subclinical hypothyroidism during pregnancy can cause metabolic disorder of blood lipid and reduce oxidative stress ability. Monitoring and intervention of blood lipid and oxidative stress status is necessary. Key words: Pregnancy; Subclinical hypothyroidism; Blood lipid; Oxidative stress