Abstract
Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.
Highlights
As an endemic disease in Cangzhou City and its surrounding areas, hyperthyroidism has attracted much attention for many years
Hyperthyroidism refers to an endocrine disease caused by hyperthyroidism and increased thyroid hormone level in blood circulation
IL-2, IL-6 and IL-8 were detected by ELISA double antibody sandwich method, and the operation was strictly in accordance with the instructions
Summary
As an endemic disease in Cangzhou City and its surrounding areas, hyperthyroidism has attracted much attention for many years. Hyperthyroidism refers to an endocrine disease caused by hyperthyroidism and (or) increased thyroid hormone level in blood circulation. The lesion is not limited to the thyroid gland, but a multi system syndrome. More than 80% of hyperthyroidism is caused by Graves' disease, which is an autoimmune disease [3]. Studies have shown that cytokines play an important role in immune regulation and immune stabilization of thyroid cells [4]. In order to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism, the changes of serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) and endothelin (ET) in serum of patients with hyperthyroidism and their correlation with thyroid function indexes were determined
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