Abstract
The presence of δ-aminolevulinic acid synthetase (EC 2.3.1.37) in homogenates and mitochondria from rat brain has been observed. Optimal conditions for the measurement of this activity are described. The enzyme activity appears to be localized in the mitochondria, although a small amount of activity is also present in the cytosol. The activity of brain δ-aminolevulinic acid synthetase was measured under conditions which are known to affect the enzyme activity in other tissues. The activity of δ-aminolevulinic acid synthetase in the brain was unaffected by a 24-h fast or by the presence of inducers such as allylisopropylacetamide, 3,5-dicarbethoxy-1,4-dihydrocollidine, or ethanol. A decrease in enzyme activity of more than 50% was observed when δ-aminolevulinic acid synthetase was measured in brain homogenates derived from rats of increasing age from 1 month to 2 years.
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