Abstract
Background: Human adenovirus (HAdV) is considered a significant enteropathogen associated with sporadic diarrhea in children. However, limited data are available regarding the epidemiology of HAdV in hospitalized children with viral diarrhea in Shanghai. The aim of this study was to characterize the epidemiology of HAdVs and describe their association with acute diarrhea in hospitalized children. Methods: A total of 674 fecal samples were subjected to PCR or RT-PCR to detect RVA, HuCV, HAstV, and HAdV. Results: HAdV infections were detected in 4.7% (32/674) of specimens, with detection rates of 13.4% (11/82), 4.6% (8/174), 3.2% (4/124), 4.1% (3/74), 2.0% (2/100), and 3.3% (4/120) from 2006 to 2011, respectively. Comprehensive detection of the four viruses revealed the presence of a high percentage (90.6%) of coinfections among HAdV-positive samples, where HAdV+RVA was the most prevalent coinfection. Of the 32 HAdV-positive samples, 50.0% (16/32) were classified as HAdV-41, and 18.8% (6/32) were classified as HAdV-3. Almost 94.0% of children infected with HAdV were less than 24 months of age. Conclusions: These results clearly indicated diversity across the HAdV genotypes detected in inpatient children with acute diarrhea in Shanghai and suggested that HAdVs play a role in children with acute diarrhea.
Highlights
BackgroundHuman adenovirus (HAdV) is considered a signi cant enteropathogen associated with sporadic diarrhea in children
Acute diarrhea is a major disease caused by various pathogenic bacteria, viruses, and parasites in all humans, but especially in children aged under 5 years. is condition remains a leading cause of morbidity and mortality worldwide, especially in developing areas
Prior to this study, limited data were available regarding the epidemiology of Human adenovirus (HAdV) in hospitalized children with viral diarrhea in Shanghai, and most studies have focused on RVA and human calicivirus (HuCV) infections [7,8,9]. erefore, we conducted this study to evaluate the epidemiology of HAdV in hospitalized children in Shanghai upon the onset of viral diarrhea
Summary
Human adenovirus (HAdV) is considered a signi cant enteropathogen associated with sporadic diarrhea in children. Limited data are available regarding the epidemiology of HAdV in hospitalized children with viral diarrhea in Shanghai. E aim of this study was to characterize the epidemiology of HAdVs and describe their association with acute diarrhea in hospitalized children. Methods: A total of 674 fecal samples were subjected to PCR or RT-PCR to detect RVA, HuCV, HAstV, and HAdV. Comprehensive detection of the four viruses revealed the presence of a high percentage (90.6%) of coinfections among HAdV-positive samples, where HAdV+RVA was the most prevalent coinfection. Conclusions: ese results clearly indicated diversity across the HAdV genotypes detected in inpatient children with acute diarrhea in Shanghai and suggested that HAdVs play a role in children with acute diarrhea
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