Abstract
The abuse of amphetamine (AMPH)-type stimulants (ATS) is a worldwide problem, and there is a need for reliable analytical methods to detect amphetamines and related designer drugs in unknown samples. Nuclear magnetic resonance (NMR) is an indispensable tool for structural elucidation and noninvasive analysis. Herein, we applied recognition-enabled “chromatographic” (REC) 19F NMR for the detection and quantitative analysis of ATS. This method allows for the detection and differentiation of up to 20 ATS and structurally similar analogs in complex mixtures, where the 19F NMR signals are precisely matched with those obtained in the analysis of each component independently. Selecting AMPH as a model analyte, we also illustrate the capability of our approach to quantitatively detect ATS. Further experiments showed that AMPH can be detected at a concentration of 1 μM in artificial urine. These results demonstrate that REC 19F NMR is an efficient and robust strategy for the determination of ATS and related derivatives.
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