Abstract
BackgroundAstroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species. Human AstVs were regarded the causative agent of viral diarrhea in children. In dogs, little is known about the epidemiology and clinical significance of AstV infection.FindingsIn this study, we collected and tested 253 rectal swabs from pet dogs; of which 64 samples (25.3%) tested positive for AstVs with diarrhea and 15 more samples (5.9%) also was identified as AstVs, however without any clinical signs. Phylogenetic analysis of 39 partial ORF1b sequences from these samples revealed that they are similar to AstVs, which can be subdivided into three lineages. Interestingly, out of the 39 isolates sequenced, 16 isolates are shown to be in the Mamastrovirus 5/canine astrovirus (CAstV) lineage and the remaining 23 isolates displayed higher similarities with known porcine astrovirus (PoAstV) 5 and 2. Further, analysis of 13 capsid sequences from these isolates showed that they are closely clustered with Chinese or Italy CAstV isolates.ConclusionsThe findings indicate that CAstVs commonly circulate in pet dogs, and our sequencing results have shown the genomic diversity of CAstVs leading to increasing number of clusters.
Highlights
Astroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species
Analysis of 13 capsid sequences from these isolates showed that they are closely clustered with Chinese or Italy Canine astroviruses (CAstVs) isolates
The findings indicate that CAstVs commonly circulate in pet dogs, and our sequencing results have shown the genomic diversity of CAstVs leading to increasing number of clusters
Summary
Astroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species. Conclusions: The findings indicate that CAstVs commonly circulate in pet dogs, and our sequencing results have shown the genomic diversity of CAstVs leading to increasing number of clusters. Canine astrovirus (CAstV) was first identified in the early 1980s and recently, it was characterized as a distinct Mamastrovirus species, which is the causative agent of gastroenteritis in pet dogs [10,11,12].
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