Abstract
The characterization of the microbubble size distribution in blood is of great practical interest for the design and the use of heart–lung machines and for clinical research. Another application is the continuous estimation of size distribution of ultrasound contrast agents. The measurement system is based on a 2-MHz pulse Doppler device and a special transducer, designed to connect to a 3/8-in. tube. The computer controlled system consists of two simultaneously working channels. The system is self-calibrating. The amplitude of a reference echo from a reflector behind the tube is used for the compensation of different acoustical properties of the tube. The minimal size of detectable gas bubbles and also the resolution of the size distribution is 1 μm in diameter. The detected size distribution will be measured continuously and saved every 5 s. Therefore it is possible to study the time course of the number and the size of gas bubbles, for example, during a heart operation. Showing the effectiveness of an arterial blood filter is done by measurements before and after the filter. Examples of the size distribution of contrast agents in different suspensions versus time after injection will be presented.
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