Abstract
To evaluate the clinical value of carcinoembryonic antigen messenger ribonucleic acid ( CEA-mRNA) detection in the diagnosis of lung carcinoma. CEA-mRNA expression was detected in 32 patients with lung carcinoma by reverse transcriptase-polymerase chain reaction ( RT-PCR) , and 11 patients with benign pulmonary diseases as control. The positive rate of CEA-mRNA was 84. 4% ( 27/ 32) in lung cancer group. And there was no positive case of CEA-mRNA in control group. The specificity was 100% and the sensitivity was 84. 4% in the diagnosis of lung carcinoma. CEA-mRNA detection by RT-PCR method may be helpful to diagnosis and differential diagnosis of lung cancer and be of clinical value.
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