Abstract
Objective To investigate the role and clinical pathological significance of PTTG and bFGF in cutaneous squamous cell carcinoma (CSCC).Methods Tissue specimens were collected from the lesions of 42 patients with CSCC and normal skin of 42 normal human controls.The protein and mRNA expressions of PTTG and bFGF were detected by immunohistochemistry and in situ hybridization in these specimens respectively.Results A significant increase was observed in the positive expression rates of PTTG and bFGF proteins [64.3％ (27/42) vs.11.9％ (5/42),73.8％ (31/42) vs.21.4％ (9/42),both P＜ 0.05] and mRNA [59.5％ (25/42) vs.7.1％ (3/42),75.0％ (29/42) vs.16.7％ (7/42),both P＜ 0.05] in the CSCC tissue specimens than in the control specimens.The protein and mRNA expressions of PTTG were positively correlated with those of bFGF (both P ＜ 0.05),and closely correlated with histological grade of CSCC (both P ＜0.05).Conclusion The high expression of PTTG and bFGF may be associated with the initiation of CSCC. Key words: Carcinoma; squamous cell; Oncogenes; Fibroblast growth factor 2
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