Abstract
BackgroundThe presence of nerve damage plays a key role in the development and prognosis of chronic pain states. Assessment of the presence and severity of a neuropathic pain component (NePC) is key in diagnosing chronic pain patients. Low back pain (LBP) and neck and shoulder pain (NSP) are highly prevalent and clinically important medical and societal problems in which a NePC is frequently present. The more severe the NePC, the worse the course of the pain, its prognosis and the results of treatment. Reliable and standardised diagnosis of the NePC remains difficult to achieve. Standardized and validated screening tools may help to reliably identify the NePC in individual chronic pain patients. The aim of this study is to validate the Dutch language versions of the PainDETECT Questionnaire (PDQ-Dlv) and the ‘Douleur Neuropathique 4 Questions’ (DN4-Dlv) for use in primary and specialist medical care settings to screen for a NePC in patients with chronic pain due to (1) LBP, (2) NSP or (3) known peripheral nerve damage (PND).Methods/designThe study design is cross-sectional to assess the validity of the PDQ-Dlv and the DN4-Dlv with 2 weeks follow-up for test-retest reliability and 3 months follow-up for monitoring and prognosis. 438 patients with chronic pain due to (1) LBP, (2) NSP or (3) PND. will be included in this study. Based on the IASP definition of neuropathic pain, two physicians will independently assess whether the patient has a NEPC or not. This result will be compared with the outcome of the PDQ-Dlv & DN4-Dlv, the grading system for neuropathic pain, bed side examination and quantitative sensory testing. This study will further collect data regarding prevalence of NePC, general health status, mental health status, functioning, pain attribution and quality of life.DiscussionThe rationale for this study is to provide detailed information on the clinimetric quality of the PDQ-Dlv and DN4-Dlv in Dutch speaking countries. Our innovative multi-factorial approach should help achieve more reliable diagnosis and quantification of a NePC in patients with chronic pain.Trial registrationThe Netherlands National Trial Register (NTR3030).
Highlights
The presence of nerve damage plays a key role in the development and prognosis of chronic pain states
The rationale for this study is to provide detailed information on the clinimetric quality, including test-retest reliability, of the Pain detect questionnaire dutch language version (PDQ-Dutch language version (Dlv)) and Douleur Neuropatique 4 Questions (DN4)-Dlv in patients with Low back pain (LBP), neck and shoulder pain (NSP) or peripheral nerve damage (PND) regarding of diagnosing a neuropathic pain component (NePC)
The key question of this study is whether a NePC as assessed by the physician is reflected in the outcome of the PDQ-Dlv and Douleur neuropathique 4 questions dutch language version (DN4-Dlv)
Summary
The rationale for this study is to provide detailed information on the clinimetric quality, including test-retest reliability, of the PDQ-Dlv and DN4-Dlv in patients with LBP, NSP or PND regarding of diagnosing a NePC. The key question of this study is whether a NePC as assessed by the physician is reflected in the outcome of the PDQ-Dlv and DN4-Dlv. In already published articles both questionnaires have proven to be useful in daily clinical practice and for research purposes with good clinimetric qualities [2,14]. By the choice for a non-selective consecutive patient recruitment in specialized pain clinics, neurology clinics as well as general practices this study aims to validate the PDQ-Dlv and DN4-Dlv in a general, unselected choronic pain population.
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