Detecting the efficacy of cyanoacrylate onto bronchial closure on an animal model

Abstract

Bronchopleural fistula is a serius complication that may lead to mortality following pulmonary resection. In our study, it was aimed to investigate the efficacy of tissue adhesive cyanoacrylate onto bronchial closure methods. During this experimental study totally 40 sheep lung and trachea were removed together for either manuel closure, stapler or cyanoacrylate. After left pneumonectomy, four groups was formed; in group I, 4/0 Premilene® suture was used with continuous horizontal matrix + over and over sutures. Bronchial stapler was used in group II. In group III, same techniques were used with group I and cyanoacrylate was applied. In group IV, bronchial suturing was achieved using 4/0 Premilene® in a continuous horizontal suture and then cyanoacrylate was applied. Each specimen was intubated with an endotracheal tube which was connected to a sphgmomanometer. The pressure level causing air bubbles was recorded inside the water. The median leakage pressure (300 mmHg) was significantly higher in group III (p0.05). Tissue adhesive cyanoacrylate was successful in preventing the leakage of bronch. We suggest that more expanded studies will provide cyanoacrylate to be used in bronchial closure after the pneumonectomy.