Abstract
Biomaterials Cells require sufficient oxygen for survival and differentiation, for example, during bone tissue regeneration. With the aid of probe molecules, two-photon phosphorescence lifetime microscopy (2PLM) can image oxygen distributions, although not in tissues lacking vasculature. Schilling et al. use electrospin polymer meshes by employing a coaxial approach to embed 2PLM probes into the cores of fibers. The fibers support bone marrow stromal cell growth and differentiation, while enabling real-time high-resolution probing of partial pressures of oxygen during the early stages of tissue repair both in vitro and in vivo. ACS Appl. Mater. Interfaces 10.1021/acsami.9b08341 (2019).
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