Abstract
Multiple sclerosis (MS) is a chronic autoimmune condition affecting the CNS. Despite recent refinements in diagnostic criteria and the availability of ancillary studies, such as cerebrospinal fluid analysis, MRI, electrophysiological studies and optical coherence tomography, MS remains a clinical diagnosis. Repeated studies have convincingly demonstrated that early treatment is critical in decreasing the rate of disease progression and, therefore, establishing the diagnosis in a timely fashion and initiating treatment is imperative. However, the latter is not always easy and recognizing disorders that may mimic MS is essential in avoiding the administration of costly and, on occasion, potentially risky therapy. Furthermore, it is important to recognize MS mimics to initiate appropriate treatment for those conditions. Prominent MS mimickers, many with features of focal neurological disease separated in both time and space, are discussed in this article. Diagnostic pearls to avoid misdiagnosis have been included.
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