Detecting list-colored graph motifs in biological networks using branch-and-bound strategy

Abstract

In this work, we study the list-colored graph motif problem, which was introduced to detect functional motifs in biological networks. Given a multi-set M of colors as the query motif and a list-colored graph G where each vertex in G is associated with a set of colors, the aim of this problem is to find a sub-graph of G whose vertex set is colored exactly as motif M. To solve this problem, we present a heuristic method to efficiently and accurately detect list-colored graph motifs in biological networks using branch-and-bound strategy. We transform the detection of list-colored graph motif to the search of connected induced sub-graphs in list-colored graph, where the vertices in the sub-graph are assigned to distinctive colors of query motif. This transformation enables our method to accurately discover the occurrences of query motif without enumerating and verifying all sub-graphs. Furthermore, a new initial vertex selection strategy based on the colors of vertices is proposed to accurately determine the search scope of motifs. Experiments conducted on metabolic networks and protein-interaction networks demonstrate that our method can achieve better performance in accuracy and efficiency in comparison to other existing methods.