Abstract

BODIPY and coumarin were assembled into a single scaffold that was cleaved upon oxidation by ClO−, thereby enabling ratiometric fluorescent detection ClO−. The ratiometric fluorescence response was distinctive (I510/I660 = 18.3) in the presence of ClO−. It was accompanied by an obvious solution color change from dark-blue to colorless. The probe is highly selective and sensitive towards ClO−, with a rapidly response time. Moreover, imaging experiments in live HeLa cells showed that the probe could readily penetrate the cell membrane and was amenable to real-time imaging of ex/endogenous ClO−. Importanty, the probe was successfully used to detect ClO− in vivo via imaging an arthritis nude mouse model.

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