Detecting atypical anomalies by non-invasive prenatal screening in advanced maternal age vs. sonographically abnormal pregnancies

Emily E Daggett,Manesha Putra,Noria Mccarther,Vanja Dimitrijevic,Shashirekha Shetty

doi:10.1016/j.ajog.2021.11.1125

Detecting atypical anomalies by non-invasive prenatal screening in advanced maternal age vs. sonographically abnormal pregnancies

Emily E Daggett, Manesha Putra + Show 3 more

Open Access

https://doi.org/10.1016/j.ajog.2021.11.1125

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Journal: American Journal of Obstetrics and Gynecology

Publication Date: Dec 23, 2021

Affiliation: Federal Reserve Bank of Cleveland, University of Colorado Anschutz Medical Campus

#Non-invasive Prenatal Screening #Sonographic Abnormalities + Show 8 more

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Abstract

Given the similar resolution for subchromosomal anomalies between karyotype (5-10Mb) and genome-wide non-invasive prenatal screening (gwNIPS) (7Mb), extrapolation of gwNIPS performance using a historical cohort is reasonable. Our objective is to estimate the post-test probabilities of gwNIPS for advanced maternal age (AMA) only vs. sonographic structural abnormalities (SA) using a historical cohort of invasive diagnostic testing.

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