Abstract
To investigate the prevalence of nodular pulmonary ossifications (POs) in patients with honeycombing on ultra-high-resolution CT (UHRCT) and to compare the detectability of nodular POs between images reconstructed using the ultra-high-resolution setting (UHR-setting) and those using the conventional setting (C-setting) on UHRCT. Twenty patients with honeycombing in the lung were evaluated retrospectively. All patients underwent non-contrast-enhanced UHRCT. Images were reconstructed with UHR-setting (matrix, 2048 × 2048; slice thickness, 0.25 mm) and with C-setting (matrix size, 512 × 512; slice thickness, 0.5 mm). Two chest radiologists independently recorded the number of nodular POs (< 4 mm diameter) in each lung lobes. Each lobe was classified as one of the following five categories according to the number of POs: C0, none; C1, 1–4 POs; C2, 5–9 POs; C3, 10–49 POs; and C4, ≥ 50 POs. The maximum CT values of the POs were measured and compared between the two settings. PO categories were significantly higher with UHR-setting than with C-setting (p < 0.001). Maximum CT values were significantly higher with UHR-setting than with C-setting (p < 0.001). Nodular POs were seen in 80% or more of patients with honeycombing and more easily detected in images reconstructed with UHR-setting than in those with C-setting.
Highlights
Abbreviations adaptive iterative dose reduction 3D (AIDR3D) Adaptive iterative dose reduction 3D computed tomography (CT) Computed tomography C-setting Conventional setting field of view (FOV) Field of view HU Hounsfield unit interstitial lung disease (ILD) Interstitial lung disease idiopathic pulmonary fibrosis (IPF) Idiopathic pulmonary fibrosis pulmonary ossifications (POs) Pulmonary ossification SD Standard deviation region of interest (ROI) Region of interest Ultra-high-resolution CT (UHRCT) Ultra-high resolution CT UHR-setting Ultra-high resolution setting usual interstitial pneumonia (UIP) Usual interstitial pneumonia
If PO is more detectable on UHRCT, UHRCT may contribute to the diagnosis of IPF
Nodular POs were seen in ≥ 80% of patients who had honeycombing on UHRCT
Summary
Abbreviations AIDR3D Adaptive iterative dose reduction 3D CT Computed tomography C-setting Conventional setting FOV Field of view HU Hounsfield unit ILD Interstitial lung disease IPF Idiopathic pulmonary fibrosis PO Pulmonary ossification SD Standard deviation ROI Region of interest UHRCT Ultra-high resolution CT UHR-setting Ultra-high resolution setting UIP Usual interstitial pneumonia. Ultra-high-resolution CT (UHRCT) scanners with 0.25 × 0.25 mm detector elements and beam collimation of 0.25 mm × 160 rows have recently become available in clinical practice[9,10,11,12,13,14]. This system can provide images with matrix size as large as 2048 × 2048 and slice thickness of 0.25 mm, which greatly increase resolution in the x–y axes and z axis[11]. If PO is more detectable on UHRCT, UHRCT may contribute to the diagnosis of IPF
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