Abstract
Methods Eight male patients with acute ST-elevation myocardial infarction underwent CMR at 3T (Siemens Verio) acutely and after >3 months. Imaging techniques included: T2-weighted imaging, late enhancement (LGE) as well as T2-mapping (3 single-shot SSFP-images), native T1-mapping (MOLLI, 11 single-shot SSFPimages), and T1-mapping 10min after 0.2mmol gadobutrol using non-product sequences. Image analysis included: 1) Visual assessment: Five independent readers assessed the presence (yes/no) of an infarct-like myocardial lesion. 2) Quantitative assessment per segment: Myocardial T2and T1-relaxation times were determined for every segment and correlated to LGE. 3) Quantitative assessment per pixel: Based on reference T2and T1relaxation times, abnormal pixels were identified and correlated to LGE.
Highlights
T1- and T2-mapping in myocardial infarction may be helpful to discriminate acute from chronic stages (AMI, CMI)
2) Quantitative assessment per segment: Myocardial T2- and T1-relaxation times were determined for every segment and correlated to LGE. 3) Quantitative assessment per pixel: Based on reference T2- and T1- relaxation times, abnormal pixels were identified and correlated to LGE
57.5%, and post-contrast T1-map in 95.0% / 91.9%. 2) The pattern of segmental abnormalities of T2- and T1relaxation times in infarcted segments compared to remote myocardium was not consistent for a confident diagnosis of AMI and CMI. 3) Pixelwise threshold-based analysis of T2- and T1-maps exposed infarcted regions in the myocardium in AMI and CMI
Summary
T1- and T2-mapping in myocardial infarction may be helpful to discriminate acute from chronic stages (AMI, CMI). Methods Eight male patients with acute ST-elevation myocardial infarction underwent CMR at 3T (Siemens Verio) acutely and after >3 months. Imaging techniques included: T2-weighted imaging, late enhancement (LGE) as well as T2-mapping (3 single-shot SSFP-images), native T1-mapping (MOLLI, 11 single-shot SSFPimages), and T1-mapping 10min after 0.2mmol gadobutrol using non-product sequences.
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