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Abstract
Deep understanding of the TIME and its influence on response to therapy is needed to improve the ability to predict and monitor immunotherapeutic responsiveness. Among cells composing the MM-TIME, granulocytic-MDSCs (G-MDSCs) have a prominent role in promoting tumor growth and inducing immunosuppression; however, their phenotype in MM is not well-established. Aim: To define the phenotype of G-MDSCs based on the immunosuppressive potential, gene regulatory networks and clinical significance of granulocytic subsets in the MM-TIME.
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