Abstract
Using enantioselective desymmetrization protocols to prepare enantiomerically enriched molecules starting from symmetrical precursors is a very economic approach to generate chirality. However, the formation of quaternary stereogenic centers remains a challenging task. Herein, the authors present an asymmetric monobenzylation of readily available 2,2-disubstituted 1,3-diols of type 1 using a catalyst formed from the chiral pyridinebisoxazoline (PyBox) ligand L* and CuCl2.
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