Abstract
Hollow microcapsules have been considered for potential applications as drug or gene carriers. This paper describes an investigation into the mechanical properties of microcapsules with a biocompatible polylactic acid (PLA) shell that can be destroyed using ultrasound irradiation. The microcapsules had a radius of 1 to 25μm and a shell thickness of 100nm to 3μm, and their response to ultrasound pulses with a center frequency of 700kHz to 2MHz was investigated. It was found that approximately 50% of capsules with a radius of 20μm were destroyed using pulses with a pressure amplitude of 50kPa and a frequency of 700kHz, which is close to the resonance frequency of the capsules.
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