Abstract
Lipids were extracted from peroxidized and nonperoxidized rat liver microsomes. The lipids were dried down under O 2-free nitrogen, and then suspended by sonication in aqueous media suitable for further testing. Lipids extracted from peroxidized microsomes destroyed 61% of the cytochrome P-450 content and 73% of the glucose-6-phosphatase activity of fresh microsomes during 90 min of incubation at 38°C. Lipids isolated from nonperoxidized microsomes had no such destructive qualities. These results suggest that when cytochrome P-450 and glucose-6-phosphatase decrease during the peroxidation of liver endoplasmic reticulum, toxic lipids may play an important role in the mechanism of destruction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
