Abstract
Desregulated microRNAs in aging-related heart failure.
Highlights
Heart failure is the major cause of death in the western world
Cardiac hypertrophy leads to a mismatch in oxygen supply and demand, which contributes to endothelial dysfunction and angiogenesis (Shiojima et al, 2005; Izumiya et al, 2006; Heineke et al, 2007)
MicroRNAs are a novel class of small non-coding RNAs with approximately 20-24 length of base, which function as endogenous suppressors of gene expression through mRNA degradation and/or translational inhibition mainly by binding to 3 -untranslated region (3 UTR) of target mRNAs (Lim et al, 2005; Van Rooij, 2011)
Summary
Heart failure is the major cause of death in the western world. Despite the development and use of standard evidence-based therapeutic strategies for heart failure like inhibition of the activity of the β-adrenergic signaling and renin-angiotensin-aldosterone system, the prevalence of heart failure is still increasing, while morbidity and mortality have not been satisfactorily improved (Hofmann and Frantz, 2013). These changes make the aged heart more susceptible to stress, leading to a high prevalence of cardiovascular diseases and heart failure (Correia et al, 2002; Dai et al, 2012a).
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