Desquamative interstitial pneumonia: report of one case and review of literature

Abstract

Objective: To analyze the clinical features, diagnosis, and treatment of desquamative interstitial pneumonia(DIP). Methods: The clinical manifestation, radiology, and pathology were analyzed in one patient with DIP in Beijing Hospital following review of the literatures. Results: The patient was a 55-year-old male presented with cough, shortness of breath and hypoxemia.Previous history of smoking and exposure to a variety of metals. A CT scan of the chest revealed diffuse ground-glass densities. A diagnosis of desquamative interstitial pneumonia (DIP) was confirmed by a thoracoscopic open lung biopsy. After treatment with hormone, the condition improved.A total of 66 cases were included in this study, the smoking groupof 20 cases, non-smokers of 46 cases.The smoking group was older than the non-smoking group [(47.5±12.1)years vs (26.1±22.5) years]; the present of chest pain, shortness of breath(4/20 vs 0/46; 8/20 vs 3/46) was higher in smoking group than in non-smoking group, and ground glass opacity in the chest image(15/20 vs 20/46) was also higher in smoking group than in non-smoking group.Pulmonary function showed more diffuse dysfunction(12/14 vs 6/13) in smoking group than in non-smoking group. Conclusions: As a rare disorder, DIP is associated with current or former cigarette smoking and many other risk factors. The clinical presents of non-smoker is atypical.DIP is curable to glucocorticoid and has a good prognosis.There is a possible of recurrence.