Desipramine and the phencyclidine derivative BTCP differently inhibit [ 3H]TCP binding to high- and low-affinity sites

Abstract

The effects of N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and desipramine on [ 3H]N-[1-(2-thienyl)cyclohexyl]piperidine ([ 3H]TCP) binding were investigated in vivo and in vitro. In the cerebrrum, both drugs were competitive inhibitors of high-affinity [ 3H]TCP binding. Conversely, in the cerebellum, they were non-competitive inhibitors of low-affinity [ 3H]TCP binding. These results imply that the different [ 3H]TCP binding sites have distinct pharmacological properties, and show that, although chemically related to TCP, BTCP has an effect similar to that of desipramine.