Abstract
The human immunodeficiency virus has been shown to be the causative agent of the acquired immunodeficiency syndrome (AIDS) and related disorders. Many thousands have already died of AIDS and the Centers for Disease Control in Atlanta have estimated that as many as 1.5 million people in the United States alone are infected with HIV. Consequently, there has been a tremendous effort, both in academia and industry, towards uncovering the structural features of viral particles, the interaction of host cellular factors involved in HIV gene expression, and the molecular mechanisms of viral replication. These efforts should provide a better understanding of AIDS pathogenesis and enable the design of effective pharmaceuticals for the treatment of HIV infection. This article reviews the current knowledge of the virus and the possible approaches towards inhibiting its replication.
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