Abstract
Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO3 (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: DOXorubicin (DOX). We also showed a prolonged pH-dependent release of DOX from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO3-and-DOX–based composite (CaNP7-DOX) in in vitro models.
Highlights
Calcium carbonate (CaCO3 ) is one of the most common inorganic materials with a wide range of applications in biomedical fields, for example, as the basis for delivery systems of biologically active substances or for biosensor construction [1]
To obtain stable monodisperse particles up to 200 nm, we investigated the influence of the reaction mixture composition on the morphological characteristics of CaCO3 nanoparticles (CaNPs)
Drug release from the tested CaNPs increased. These results suggest that CaNP7 can be can be further investigated as a nanocarrier for drug delivery
Summary
Calcium carbonate (CaCO3 ) is one of the most common inorganic materials with a wide range of applications in biomedical fields, for example, as the basis for delivery systems of biologically active substances or for biosensor construction [1]. A large number of studies have been published aimed at the design of Ca2+ -based delivery systems for anticancer drugs (including DOXorubicin; DOX) [4,5]. Most of the studies on the preparation and characterization of nanomaterials based on CaCO3 involve porous particles in the micrometer size; the advantages of such materials include the large surface area (due to the porosity of such structures) available for interaction with the drug; the large particle size imposes significant limitations in the use of such materials in vivo [6,7]. In the case of passive targeting, nanomaterials with sizes
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