Abstract
Here we report on an oxygen microbubble that has increased circulation and contrast persistence to treat tumor hypoxia during X-ray therapy. In recent work, oxygen microbubbles injected directly into tumors were shown to oxygenate hypoxic tumors and improve radiation therapy [1]. Here, we investigate oxygen microbubbles designed for intravenous, rather than intra-tumoral, injection. Oxygen microbubbles were designed with two phospholipid shell compositions, DSPC (C18:0) and DBPC (C22:0). DBPC microbubbles showed a significant increase in ultrasound contrast persistence in vivo in the mouse kidney, and this composition may be ideal for an intravascular microbubble injection to treat tumor hypoxia in radiation oncology.
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