Abstract
In this present study, a new co-crystal of azithromycin with nicotinamide and naringenin has been developed with improved solubility. Azithromycin is a class II drug with poor aqueous solubility; hence an attempt has been made to improve its solubility through co-crystallization technology. In this study, the coformers selected were nicotinamide and naringenin based on ease of hydrogen bond formation. The co-crystal of azithromycin with nicotinamide was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The co-crystal of azithromycin with naringenin was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The formation of the co-crystal was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffractometry (PXRD). AzithromycinNicotinamide cocrystal 1:1 prepared by the dry grinding method was increased by 6.85 fold as compared to pure drug. Azithromycin-Naringenin cocrystal 1:1 prepared by solvent evaporation method was increased by 3.06 fold as compared to pure drug.
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