Abstract
A novel potentiometric sensor with high selectivity and sensitivity has been developed for the determination of heparin, based on the modification of heparin-imprinted polymer film onto a glassy carbon. The performance of the developed heparin sensor was evaluated, and the results indicated that a sensitive potentiometric sensor could be fabricated. The obtained heparin sensor shows high-selectivity monitoring of heparin, shorter response time (<4min), wider linear range (0.003–0.7μM), lower detection limit (0.001μM), and satisfactory long-term stability (>2months). The potentiometric sensor was successfully applied to the determination of heparin in heparin sodium injection with recoveries between 97.1% and 110.0%.
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