Designing of click-derived 1,2,3-triazoles as potential anti-bacterial agents and sensor towards Al(III) ion in aqueous medium

Abstract

Aluminium is useful in various industrial applications and pharmaceuticals but its excess can pose serious health risks. There lies a need for the development of simple, cost-effective sensors for detection of Al(III) ion and the triazole appended moieties are potential chemosensors. Owing to these factors, we have utilized Click-approach for the synthesis of 1,2,3- triazole appended probe 5a that shows good selectivity and sensitivity towards Al(III) ion in UV–visible spectroscopy with an association constant value of 1.9 × 106 M−1 and limit of detection value of 0.08 × 10−7 M. The binding mechanism of synthesized receptor and Al(III) ion has studied via 1H NMR and DFT calculations. Keeping in view the biological activity of triazoles, the minimum inhibitory concentration (MIC) values of triazoles 5a-5d have been investigated and compared towards bacterial strains E. coli and S. aureus, resulting in the lowest MIC value of 5c against the gram-positive S. aureus strain. The interaction between 5c and S. aureus protein has been studied using theoretical tool of molecular docking.