Abstract
Magnetic drug targeting is a drug delivery system applicable to cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. In the present research, casein-coated iron oxide nanocarriers (CCIONPs) of core shell nanostructure have been described as being applicable to magnetic drug targeting. The structure, morphology, and composition of prepared magnetic nanoparticles were determined by analytical techniques like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Electron diffraction (ED), X-ray diffraction (XRD), Zeta potential, Dynamic light scattering (DLS), Mossbauer and Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Vibrating sample magnetometery (VSM)) and in vitro cytotoxicity analysis. Magnetization studies of CCIONPs conducted at room temperature using a vibrating sample magnetometer suggested their superparamagnetic nature as having a saturation magnetization (Ms) of 64 emu g−1 at an applied magnetic field of 5 kOe. The size of the magnetic polymeric nanoparticles was found to lie in the range of 73.9 ±0.36 nm, and the particles exhibited superparamagnetic behavior. The prepared particles could be used as a drug carrier for controlled and targeted drug delivery.
Highlights
The srtudy of submicron magnetic entities is exciting and they have been extensively researched and employed in biomedical applications such as targeted drug delivery, magnetic resonance imaging, hyperthermia, etc. (Gyergyek et al 2008)
The structure, morphology, and composition of prepared magnetic nanoparticles were determined by analytical techniques like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Electron diffraction (ED), X-ray diffraction (XRD), Zeta potential, Dynamic light scattering (DLS), Mossbauer and Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Vibrating sample magnetometery (VSM)) and in vitro cytotoxicity analysis
In order to study the effect of composition of iron oxide in casein nanoparticles (CNPs), the casein-coated iron oxide nanoparticles (CCIONPs) containing different iron oxides were prepared by changing the oxidation form of iron as well as its molar ratio
Summary
The srtudy of submicron magnetic entities is exciting and they have been extensively researched and employed in biomedical applications such as targeted drug delivery, magnetic resonance imaging, hyperthermia, etc. (Gyergyek et al 2008). Preparation of casein-coated iron oxide nanoparticles (CCIONPs) In order to investigate the crystalline nature of prepared casein and the electron diffraction (ED) of the iron oxideimpregnated nanoparticles, studies were performed using a Morgagni 268-D transmission rlectron microscope.
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