Abstract
An excellent candidate as a proton substitute in man-made organic reactions is a Lewis acid. The goal of the research was to engineer an artificial proton of a special shape, which could be utilized as an effective tool for chemical reactions, by harnessing the high reactivity of the metal atom towards a variety of functional groups. Such a concept was initially researched by examining the influence of a specially designed organometallic reagent on a typical organic reaction. Michael addition of simple organolithium and magnesium reagent to aromatic aldehydes in the presence of a bulky organoaluminum reagent is described as an example of the concept. The successful discrimination observed led to examine the more intricate question of enantioface differentiation. A variety of Lewis acid reagents were utilized for Diels-Alder, aldol, and ene reactions with high enantioselectivities. The origins of the selectivity of these reactions are discussed. The review describes these points with a variety of designer Lewis acids selected to illustrate the utility of the concept.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
