Abstract
Abstract A type of brush-shaped copolymer with natural DNA as the main chain is synthesized. Multiple alkyne groups are introduced onto the phosphate backbone of natural DNA via an O–H insertion reaction, thus rendering the DNA sequence reactive for the subsequent grafting with azide-terminated poly(ethylene glycol) (PEG-N3) by click reaction. This is the first synthesis of natural DNA as a main chain brush-shaped copolymer. The resulting novel copolymer may have potential for electrochemical DNA biosensors and gene delivery.
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