Abstract
Nanocarriers that respond to the magnetic field are explored for their potential to deliver anticancer drugs and enhance chemotherapeutic efficacy. In this paper, we report NIR-II radiation-absorbing and magnetically-responsive rod-shaped CuFe 2 S 3 nanoparticles (NPs) as drug delivery agents. The NPs are characterized by employing imaging and spectroscopic techniques. The CuFe 2 S 3 NPs are coated with a synthesized poly-β-cyclodextrin polymer. The size and shape of the NPS are determined. The transmission electron microscopic imaging reveals the rod shapes of the NPs. The magnetic properties are studied and superparamagnetic behavior is observed. The chemotherapeutic drug, i.e, camptothecin (CPT) is loaded on the nanocarrier. The polymer-coated NPs are observed to possess an excellent CPT adsorption of about 98%. The in-vitro CPT-release kinetics is investigated for about 320 hours. The nanocarrier is loaded with CPT and tested for anticancer potential against breast cancer (MDA-MB-231) cell lines. In addition, the cell inhibition mechanism is studied and the apoptotic extent is elaborated. The performance of the poly-CD-coated CuFe 2 S 3 NPs as a CPT-carrier is explored in detail and discussed.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
