Abstract
Glycodendrimers have attracted considerable interest in the field of dendrimer sciences owing to their plethora of implications in biomedical applications. This is primarily due to the fact that cell surfaces expose a wide range of highly diversified glycan architectures varying by the nature of the sugars, their number, and their natural multiantennary structures. This particular situation has led to cancer cell metastasis, pathogen recognition and adhesion, and immune cell communications that are implicated in vaccine development. The diverse nature and complexity of multivalent carbohydrate–protein interactions have been the impetus toward the syntheses of glycodendrimers. Since their inception in 1993, chemical strategies toward glycodendrimers have constantly evolved into highly sophisticated methodologies. This review constitutes the first part of a series of papers dedicated to the design, synthesis, and biological applications of heterofunctional glycodendrimers. Herein, we highlight the most common synthetic approaches toward these complex molecular architectures and present modern applications in nanomolecular therapeutics and synthetic vaccines.
Highlights
Glycosciences and Nanomaterial Laboratory, Université du Québec à Montréal, P.O
This review constitutes part one of a series dedicated to the design, synthesis and
This review constitutes part one of a series dedicated to the design, synthesis and applications of heterobifunctional glycodendrimers
Summary
As stated above, owing to their over expression in a number of cancer cells, TACAs from the group of O-linked mucins have been the subject of intense activity to generate anticarbohydrate cancer vaccines [41,42,43,44]. The initial results of the clinical trial demonstrated that patients developed high levels of Tn-specific antibodies These antibodies recognized Tn-expressing human tumor cells which were killed through a complement-. 9A7 (mAb), the glycosylated scaffold can constitute an attractive strategy for the design of new presence of the second TF epitope did not interfere with the recognition of Tn. Unfortugeneration vaccines once grafted to a suitable T helper cell epitope similar to those described nately, the study did not show the result of reversed anti-TF antibody data. Unfortugeneration vaccines once grafted to a suitable T helper cell epitope similar to those described nately, the study did not show the result of reversed anti-TF antibody data This heteropreviously through the Lys indicated by the arrow on 48.
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