Design, Synthesis, Spectral Characterization, DNA Binding and Antibacterial Studies of Ternary Metal Complexes with 1,10 Phenanthroline and 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone

Abstract

Bivalent metal complexes having the composition M(Phen)Cl2 (where, M = Cu(II), Ni(II) and Co(II); Phen = 1,10-Phenonthroline) are reacted with 2-acetylthiophene-4-phenyl-3-thiosemicarbazone (ATPT) to produce ternary complexes with molecular formula [M(Phen)(ATPT)Cl2] H2O. The complexes are characterized using physical (molar conductivity) and spectral (mass spectra, infrared and electronic spectroscopies) methods. Electrochemical behavior of complexes was uncovered using cyclic voltammetry. DNA binding properties of the complexes are determined by using absorption UV-Visible spectrophotometry. Metal complexes are screened for their antibacterial activity by using agar well diffusion method against pathogenic bacterial strains viz. Gram–ve such as Escherichia coli, Klebsiella Pneumonia and Gram+ve such as Staphylococcus aureus, Bacillus cereus. The [Ni (Phen)(ATPT)Cl2] 0.5 H2O complex inhibits bacteria more stronger than any other complex.
 HIGHLIGHTS
 
 Ternary Metal Complexes with 1,10 Phenanthroline and 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone are synthesized
 The complexes are characterized using physico-chemical, spectral and electrochemical methods
 DNA binding properties of the complexes are determined
 Metal complexes are screened for their antibacterial activity
 The [Ni (Phen)(ATPT)Cl2] 0.5 H2O complex inhibits bacteria more effectively
 
 GRAPHICAL ABSTRACT