Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases

Sajjad Hussain Sumrra

doi:10.11648/j.jddmc.20160203.11

Abstract

A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.

Highlights

Metals based nitrogen and oxygen containing Schiff bases have been of great interest due to their extensive pharmacological activities [1]
All the synthesized metal(II) complexes were intensely colored except Zn(II) complexes which were white and all complexes were microcrystalline in nature
Three bidentate N, O donor type Schiff base ligands were prepared by the condensation reaction of ethylene-1,2diamine with 3,4,6-trimethylacetophenone, 2aminoacetophenone and 2,4-dimethylacetophenone in 1:2 molar ratio These ligands were further complexed with transition metals to produce their new metal complexes

Summary

Introduction

Metals based nitrogen and oxygen containing Schiff bases have been of great interest due to their extensive pharmacological activities [1]. A number of Schiff base metal complexes have been studied for biological activities like antibacterial [5], antifungal [6], antitumor [7], anticancer [8], anti-inflammatory [9], anticonvulsant [10], antiviral [11], ant iproliferative [12] and analgesic [13]. Metal complexes of ethylene-1,2diamine are known to possess following biological activities such as antibacterial [14], antifungal [15], anticancer [16] and ant idiabetic [17]. In view of the significant structural, biological behavior and applications of ethylenediamine compounds, we wish to report the synthesis of a new class of Schiff bases (L1)-(L3), derived from the reaction of ethylene1,2-diamine with 3,4,6-trimethylacetophenone, 2aminoacetophenone and 2,4-dimethylacetophenone respectively, and their Co(II), Cu(II), Ni(II) and Zn(II) metal

Methods

Results

Conclusion