Abstract
A unique series of amide-scutellarin derivatives were designed and synthesized in order to develop the function of scutellarin further. The antiproliferative activity of all target compounds against two human leukemia cell line was evaluated. Among them, compounds 6g and 7c displayed the most antitumor activities against HL-60 and THP-1 cells. Moreover, all compounds were also assayed for their neuroprotective activity against hydrogen peroxide (H2O2)-induced PC12 cell injury, and the majority of the compounds had moderate to good neuroprotective properties. These findings confirmed that these target compounds could be used as antileukemia or neuroprotective candidates in the future.
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