Abstract
A series of pyrrolidine derivatives were synthesized and evaluated for their ability to inhibit neuraminidase (NA) of influenza A virus (H3N2). All compounds were synthesized in good yields starting from commercially 4-hydroxy- l-proline using a suitable synthetic strategy. These compounds showed potent inhibitory activity against influenza A neuraminidase. Within this series, five compounds, 6e, 9c, 9e, 9f, and 10e, have good potency (IC 50 = 1.56–2.71 μM) which are compared to that the NA inhibitor Oseltamivir (IC 50 = 1.06 μM), and could be used as lead compoundS in the future.
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