Abstract
Aim:WHO Malaria report 2017 estimated 216 million cases of malaria and 445,000 deaths worldwide, with 91% of deaths affecting the African region.Results/methodology:Microwave promoted the synthesis of cycloalkyl amine substituted isoindoline-1,3-dione-4-aminoquinolines was urbanized for evaluating their antiplasmodial activities. Compound with the optimum combination of propyl chain length and hydroxyethyl piperazine proved to be the most potent among the synthesized scaffolds against chloroquine-resistant W2 strain of Plasmodium falciparum with an IC50 value of 0.006 μM. Heme-binding along with density functional theory studies were further carried out in order to delineate the mechanism of action of the most active compound.Conclusion:The synthesized scaffold can act as a therapeutic template for further synthetic modifications toward the search for a new antimalarial agent.
Highlights
C4/C5 cycloalkyl amine substituted isoindoline-1,3-dione-4-aminoquinolines have been designed, synthesized and evaluated against the chloroquine-resistant strain of P. falciparum resulting in the identification of a potential lead
The promising antiplasmodial potential exhibited by the present series of C4/C5 cycloalkyl amine substituted isoindoline-1,3-dione-4-aminoquinolines is suggestive of the fact that these molecules can act as therapeutic templates for the design of new antimalarials with a low incidence of resistance
Summary
WHO Malaria report 2017 estimated 216 million cases of malaria and 445,000 deaths worldwide, with 91% of deaths affecting the African region
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