Abstract
Abstract2,2′ (2,4‐dioxopentane‐3,3‐diyl) bis(diazene‐2,1‐diyl) dibenzoic acid was produced in this work, which was derived from the coupling reaction between two moles of diazonium salt and one mole of acetylacetone in an alkaline medium. Some derivatives based on this starting material were investigated. The structures of the good yielded synthesized composites were well characterized by different spectral techniques such as IR,1H‐ NMR,13C‐ NMR, and mass spectrometry. Due to the outrageous spread of cancer, these compounds were tested for the cytotoxicity against human tumor cells (HEPG‐2) and (MCF‐7) as a wide spread type of cancers in Egypt. The study illustrated that compounds11aand11bhad a very powerful effect on two separate cell lines (HEPG‐2 and MCF‐7) and compounds8and6had a strong effect. The results of anticancer were supported by molecular docking and 2D‐QSAR modeling. In addition to testing the compounds as anticancer drugs, they were examined as antioxidant by using [DPPH] technique, antimicrobial activity (gram‐positive and gram‐negative) and antifungal activity which provided satisfactory results. The fluorescence properties were tested as an analytical application for the produced substances with good results.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
