Abstract
Ferulic acid and p-coumaric acid, cinnamic derivatives of phenolic acid, have antibacterial, prooxidant, and antioxidant effects. In this study ferulic acid and p-coumaric acid amide derivatives were investigated for their antibacterial and antioxidant properties are described in this communication. The most effective conjugates against B subtilis were 5b (IC50: 215 ± 1.3 μM) and 4d (IC50: 336 ± 2.7 μM) and against P. aeruginosa were 4b (IC50: 365 ± 2.8 μM) and 5b (IC50: 341 ± 3.6 μM), whereas the none of conjugates were more effective against E. coli than reference Kanamycin. Conjugates 5b was the most effective against B subtilis of all the synthesized conjugates, with IC50 values of (IC50: 215 ± 1.3 μM). The free radical scavenging capacity of each compound was determined using the DPPH and ABTS assays. Conjugates 4b (IC50: 53 ± 3.6 μM), 4c (IC50: 58 ± 1.3 μM), 4d (IC50: 57 ± 2.5 μM), 5b (IC50: 29 ± 1.5 μM) and 4a (IC50: 56 ± 4.3 μM) have greater antioxidant capacity than ferulic acid and ascorbic acid in the DPPH assay. Whereas in the ABTS assay, compounds 4b (IC50: 7 ± 1.8 μM), 5b (IC50: 5 ± 0.7 μM), 4a (IC50: 9 ± 3.2 μM), 4g (IC50: 7 ± 2.3 μM), and 5a (IC50: 8 ± 4.3 μM) showed more antioxidant activity than ferulic acid, p-coumaric acid and ascorbic acid. Thus, a large library of compounds derived from bile acid can be easily synthesized for extensive structure-activity relationship studies in order to identify the most appropriate antibacterial and antioxidant agents.
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