Abstract
AbstractIn order to discover potential ryanodine receptor insecticides, 21 novel anthranilic diamides analogues (C, D, E, and F) containing amide, carbamate, urea, and thiourea moieties were designed and synthesized based on bioisosteric approach. The biological assays against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that these compounds displayed moderate to excellent activities. Especially, compound D1 showed 100% larvicidal activities against oriental armyworm at 1.0 mg•L−1, equivalent to the standard chlorantraniliprole (100%, 1.0 mg•L−1). Moreover, the larvicidal activity of D1 against diamondback moth was 100% at 0.1 mg•L−1, more effective than that of chlorantraniliprole (90%, 0.1 mg•L−1). Therefore, D1 can be used as a new lead structure for the development of insecticidal agents. The preliminary structure‐activity relationship showed that the introduction od carbamate groups into 4‐position on the benzene ring of the N‐phenylpyrazole moiety has a positive effect on the larvicidal activities.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
