Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4‐aminoquinoline‐1,3,5‐triazine derivatives

Abstract

AbstractA series of 4‐aminoquinoline 1,3,5‐triazine derivatives were synthesized and evaluated for anticancer activity against cancer cell lines HeLa, MCF‐7, HL‐60, HepG2 where these derivatives exert significant anticancer activity. The molecules found nontoxic against MCF‐12A. The molecules also showed potent inhibition of EGFR‐TK as compared to eroltinib in enzyme‐based assay. The newly synthesized derivatives were screened for their in vitro antibacterial and antifungal activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, Aspergillus niger, Aspergillus fumigatus using cefixime and fluconazole as standard. Antibacterial screening results suggest that compound 7c showed potent activity against S. aureus, P. aeruginosa, and P. vulgaris. In antifungal screening, compound 7b showed significant activity against A. niger, A. fumigatus and moderate activity against C. albicans.