Design, synthesis and study of novel indoxine derivatives

Abstract

Keeping in view the pharmacological properties of indolinones as promising scaffold as kinase inhibitors, herein, a novel series of N- benzyl-4-phenyl-5-cyano-indoxine moiety were synthesized, studied by molecular docking, and fully characterized by spectroscopic techniques. All the prepared compounds were evaluated for their cytotoxicity attributes against a panel of tumor cell lines, including cardiovascular disease (ALA-564). They displayed moderate to promising antiproliferative effects toward ALA-564. The molecular docking studies demonstrated that our prepared compounds were potentially bound to 4UWC active site through essential H-bond and other vital interactions with critical binding residues.