Abstract
Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins were rationally designed and synthesized. Preliminary bioassay showed that compounds 7c, 7h and 7l exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50μg/mL, 7c exhibited good activity against S. sclerotiorum with median effective concentration (EC50) of 4.08μg/mL, while the positive control coumoxystrobin showed EC50 of 1.00μg/mL. In addition, 7d showed better fungicidal activity with a lower EC50 value of 7.65μg/mL against Botrytis cinerea than that of positive control trifloxystrobin with its EC50 value of 21.96μg/mL. This study indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurin was a promising fungicide lead deserved for further study.
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