Abstract
With the increasing antibiotic resistance of bacterial strains, alternative methods for infection control are in high demand. Quorum sensing (QS) is the bacterial communication system based on small molecules. QS is enables bacterial biofilm formation and pathogenic development. The interruption of QS has become a target for drug discovery, but remains in the early experimental phase. In this study, we synthesized a set of six compounds based on a scaffold (alkyl-quinoxalin-2(1H)-one), new in the anti-QS of Gram-negative bacteria Aeromonas caviae Sch3. By quantifying biofilm formation, we were able to monitor the effect of these compounds from concentrations of 1 to 100 µM. Significant reduction in biofilm formation was achieved by 3-hexylylquinoxalin-2(1H)-one (11), 3-hexylylquinoxalin-2(1H)-one-6-carboxylic acid (12), and 3-heptylylquinoxalin-2(1H)-one-6-carboxylic acid (14), ranging from 11% to 59% inhibition of the biofilm. This pilot study contributes to the development of anti-QS compounds to overcome the clinical challenge of resistant bacteria strains.
Highlights
The significant improvement of human health by the discovery of penicillin is undeniable.With the increase in bacterial strains resistant to virtually every clinically approved antibiotic, drug discovery research is facing the challenge of sustaining infection therapy [1,2]
This study provides anti-quorum sensing compounds for Aeromonas caviae Sch3 based on a scaffold benefiting future studies
Given the urgent need for new therapies to overcome the current bacterial antibiotic resistance problem, our study contributes to the research effort by providing a compound set and a valuable scaffold new for anti-Quorum sensing (QS) in Aeromonas caviae
Summary
The significant improvement of human health by the discovery of penicillin is undeniable. Quorum sensing describes the bacterial cell–cell communication based on small molecules called autoinducers [4]. In Gram-negative bacteria, QS is a key function for the formation of biofilm. The biofilm maintains bacterial bacteria fromand antibiotic influences, and[6]. Sch is a Gram-negative and for an bacterial viability, shields bacteria from antibiotic and provides anbacterium environment environmental opportunistic pathogen of animals humans [7]. Gram-negative an gastroenteritis, environmental wound infections, bacteremia, and, frequently, respiratory infections, hepatobiliary infection, opportunistic pathogen of animals andless humans [7]. A remarkable ability to bacteremia, lesstract frequently, respiratory infections, hepatobiliary infection, urinary tract colonize aand broad variety of environments, relying on their ability biofilm production andvariety cell–cell infections, ocular infections [7]. Thefrom majorcommon autoinducers produced lactones (AHLs), metabolism which are derived components of by theAeromonas bacterial are N-butanoyl homoserine lactone (C4-AHL)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
