Design, synthesis and evaluation of a chiral propranolol selector

Abstract

Synthesis of enantiomerically pure ( S)-(−)-propranolol, the most active of the widely used beta-blockers adrenergics, was achieved using a new chiral stationary phase (CSP) for the separation of a derivative. This simple methodology shows a significant improvement in the separation of the enantiomers of a propranolol derivative over previous methods.